Antimalarial Agents: Design and Mechanism of Action
Graham L. Patrick
Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists.
- Consolidates both past and current developments in the discovery and design of antimalarial drugs
- Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds
- Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected
Color Atlas of Medical Bacteriology 3th Edition
This unique visual reference presents more than 750 brilliant, four-color images of bacterial isolates commonly encountered in diagnostic microbiology and the methods used to identify them, including microscopic and phenotypic characteristics, colony morphology, and biochemical properties.
- Chapters cover the most important bacterial pathogens and related organisms, including updated taxonomy, epidemiology, pathogenicity, laboratory and antibiotic susceptibility testing, and molecular biology methodology
- Tables summarize and compare key biochemical reactions and other significant characteristics
- New to this edition is a separate chapter covering the latest developments in total laboratory automation
- The comprehensive chapter on stains, media, and reagents is now augmented with histopathology images
- A new Fast Facts chapter presents tables that summarize and illustrate the most significant details for some of the more commonly encountered organisms
Congenital and Perinatal Infections
by Jennifer S. Read
CONGENITAL AND PERINATAL INFECTIONS provides a concise and clinically-oriented primer on the congenital and perinatal infections likely to present in clinical practice. Written with the busy clinician in mind, it combines easy accessibility with state-of-the-art information on the epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and prevention of congenital and perinatal infections. Eschewing the notion that congenital and perinatal infections only encompass agents from the TORCH group of pathogens, this volume offers comprehensive information on the spectrum of viral, bacterial, and parasitic infections that can manifest in mother or child. Combined with its brevity and emphasis on clinical management, CONGENITAL AND PERINATAL INFECTIONS is a definitive new guide to understanding this challenging group of infections.
Escherichia coli, a Versatile Pathogen
by Gad Frankel
Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
by Lloyd N. Friedman
Entirely updated and revised, the 6th edition of Clinical Tuberculosis continues to provide the TB physician with a definitive and erudite account of the latest techniques in diagnosis, treatment and control of TB, including an overview of the latest guidelines from the CDC and WHO. With an increased emphasis on the clinical aspects and treatment, this book will be an invaluable resource to the TB practitioner in public health or clinical practice and an ideal reference to laboratory staff. Key Features
- Completely updated and reorganized
- Includes brand new chapters on radiology and an overview of the latest WHO, ATS/CDC/IDSA, ERS, NICE, CTS and IUATLD guidelines
- Clinically focused to provide up-to-date guidance on diagnosis, treatment and control
- Edited by three renowned experts in the field of tuberculosis
Succinct Pediatrics: Evaluation and Management for Infectious Diseases and Dermatologic Disorders
by Leonard G. Feld MD PhD MMM
Confidently evaluate evidence-based information to make timely and accurate diagnoses and treatment decisions! The second volume features 58 topics with key points and detailed therapies in infectious diseases and dermatologic disorders. Obtain core knowledge needed for medical decision making and evidence-based information to provide insight into diagnostic tests and treatment modalities. Topics include:
- Infectious Diseases
- Bacterial Infections
- Fungal Infections
- Common Infectious Conditions
- Viral Infections
- Parasitic Infections
- Plus much more...
Antibiotic Resistance: Mechanisms and New Antimicrobial
by Kateryna Kon
Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections. Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance.
- Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistance
- Provides information on modern methods used to fight antibiotic resistance
- Covers a wide range of alternative methods to fight bacterial resistance, offering the most complete information available
- Discusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developments
- Offers the most up-to-date information in fighting antibiotic resistance
- Includes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries
by Emilio Bouza
Microbial transmission, the processes by which microbes transit to new environments, is a significant and broad-reaching concept with applications throughout the biological sciences. This collection of reviews, edited by an international team of experts studying and working across a range of disciplines, explores transmission not just as an idea in disease but as a fundamental biological process that acts in all domains of nature and exerts its force on disparate size scales, from the micro to the macro, and across units of time as divergent as a single bacterial replication cycle and the entire course of evolution.
Bacterial Pathogenesis: A Molecular Approach
by Brenda A. Wilson
This highly anticipated update of the acclaimed textbook draws on the latest research to give students the knowledge and tools to explore the mechanisms by which bacterial pathogens cause infections in humans and animals. Written in an approachable and engaging style, the book uses illustrative examples and thought-provoking exercises to inspire students with the potential excitement and fun of scientific discovery. Completely revised and updated, and for the first time in stunning full-color, Bacterial Pathogenesis: A Molecular Approach, Fourth Edition, builds on the core principles and foundations of its predecessors while expanding into new concepts, key findings, and cutting-edge research, including new developments in the areas of the microbiome and CRISPR as well as the growing challenges of antimicrobial resistance. All-new detailed illustrations help students clearly understand important concepts and mechanisms of the complex interplay between bacterial pathogens and their hosts. Study questions at the end of each chapter challenge students to delve more deeply into the topics covered, and hone their skills in reading, interpreting, and analyzing data, as well as devising their own experiments. A detailed glossary defines and expands on key terms highlighted throughout the book. Written for advanced undergraduate, graduate, and professional students in microbiology, bacteriology, and pathogenesis, this text is a must-have for anyone looking for a greater understanding of virulence mechanisms across the breadth of bacterial pathogens.
100 Questions & Answers About Hepatitis C: A Lahey Clinic Guide
by Stephen C. Fabry
Whether you're a newly diagnosed patient, a friend or relative of someone with Hepatitis C, this book offers help. Written by two physicians from Lahey Clinic, Dr. Fabry and Dr. Narasimhan, this book provides authoritative, practical answers to the most common questions about Hepatitis C.